NeuroscienceNeurobiology of DiseasePeer-reviewed
Neuronal Modeling of Alternating Hemiplegia of Childhood Reveals Transcriptional Compensation and Replicates a Trigger-Induced Phenotype
John P. Snow, Grant M. Westlake, Lindsay K. Klofas…·Kevin C. Ess
This study uses iPSC-derived neurons from AHC patients to show elevated ATP1A3 mRNA and a stress-induced hyperactivity phenotype, suggesting potential for therapeutic screening.