Kevin C. Ess

This study identifies a mechanism by which tumor endothelium regulates fatty acid delivery to metastases, showing that mTORC1 inhibition in endothelial cells reduces metastatic disease by impairing T cell fatty acid uptake.

This study shows that TSC2 mutant cells exhibit early neurodevelopmental abnormalities and DNA methylation changes, suggesting early gene regulation disruption in TSC.

The paper develops a machine learning tool to identify balloon cells in TSC brain tissues using imaging mass cytometry and a custom antibody panel.

This study uses patient-derived neurovascular units to show that TSC2 mutations impair BBB function, which can be rescued by wild-type astrocytes or rapamycin treatment.

This study identifies the role of 4EBP1/2 dephosphorylation in inducing quiescence in embryonic neural stem cells, offering insights into adult brain development and potential therapeutic strategies.

This study uses iPSC-derived neurons from AHC patients to show elevated ATP1A3 mRNA and a stress-induced hyperactivity phenotype, suggesting potential for therapeutic screening.

The paper compares dual isogenic human iPSC pairs to identify functional alterations caused by an epilepsy-associated SCN1A mutation and its interaction with genetic background.