Rescue of Impaired Blood-Brain Barrier in Tuberous Sclerosis Complex Patient Derived Neurovascular Unit
Jacquelyn Ann Brown, Shannon L. Faley, Monika Judge, Patricia Ward, Rebecca A. Ihrie, Robert Carson, Laura C. Armstrong, Mustafa Şahin, John P. Wikswo, Kevin C. Ess, M. Diana Neely
This study uses patient-derived neurovascular units to show that TSC2 mutations impair BBB function, which can be rescued by wild-type astrocytes or rapamycin treatment.
Journal of Neurodevelopmental Disorders · May 23, 2024Peer-reviewedNeuroscience