Hypothalamic oligodendrocytes regulate systemic energy balance through Notch-dependent state transitions
Simona Hankeová, Margaret Hayne, Mathijs P. Verhagen, Greg Farber, Michelle Dourado, Dewakar Sangaraju, Kayla Lee, Praveen Krishnamoorthy, Ronal Peralta, Kerstin Seidel, Kai Barck, Amy Shelton, Manal Sadek, Pamela Chan, Adel ElSohly, , Lluc Mosteiro
This study identifies Notch signaling in hypothalamic oligodendrocytes as a regulator of systemic energy balance, showing that inhibiting Notch ligands leads to weight loss and metabolic changes.
bioRxiv · Jul 31, 2026 · PreprintPhysiology