Christian W. Siebel

This study shows that Notch signaling regulates CD8+ T cell exhaustion and differentiation during chronic infection by promoting the transition from progenitor to effector-like cells and preventing terminal exhaustion.

This study identifies Notch signaling in hypothalamic oligodendrocytes as a regulator of systemic energy balance, showing that inhibiting Notch ligands leads to weight loss and metabolic changes.

The paper identifies a novel transient SOX9+ pericentral hepatocyte population in acute liver injury that mediates early tissue repair and immune modulation.

Epiregulon infers single-cell TF activity using ATAC-seq and RNA-seq to predict drug response and identify drivers of cell state.

This study identifies the Jag2/Notch1 signaling axis as critical for sebaceous gland differentiation and progenitor cell regulation in adult skin.