Author

Pamela Chan

Genentech

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Adel ElSohly· 1 shared Alicja CzubatyiD· 1 shared Allen GoodmaniD· 1 shared Amy Shelton· 1 shared Amy WangiD· 1 shared Andreas LoukasiD· 1 shared Andrew Leaver‐FayiD· 1 shared Andrew M. WatkinsiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperPhysiology

Adel ElSohly

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Hypothalamic oligodendrocytes regulate systemic energy balance through Notch-dependent state transitions

Simona Hankeová, Margaret Hayne, Mathijs P. Verhagen, Greg Farber, Michelle Dourado, Dewakar Sangaraju, Kayla Lee, Praveen Krishnamoorthy, Ronal Peralta, Kerstin Seidel, Kai Barck, Amy Shelton, Manal Sadek, Pamela Chan, Adel ElSohly, , Lluc Mosteiro

This study identifies Notch signaling in hypothalamic oligodendrocytes as a regulator of systemic energy balance, showing that inhibiting Notch ligands leads to weight loss and metabolic changes.

bioRxiv · Jul 31, 2026 · PreprintPhysiology

Lab-in-the-loop therapeutic antibody design with deep learning

Nathan C. Frey, Isidro Hötzel, Samuel Stanton, Ryan L. Kelly, Robert G. Alberstein, Emily K. Makowski, Karolis Martinkus, Daniel Berenberg, Jack J. Bevers, Tyler Bryson, Pamela Chan, Yongmei Chen, Alicja Czubaty, Tamica D’Souza, Henri Dwyer, , Vladimir Gligorijević

This paper introduces a machine learning framework for therapeutic antibody design that integrates computational methods with experimental validation, resulting in significantly improved binding affinity for multiple targets.

bioRxiv · Feb 19, 2025 · PreprintBioengineering