Recapitulation of clinical and molecular hallmarks of lipid-induced hepatic insulin resistance in a zonated, vascularized human liver acinus microphysiological system during metabolic dysfunction-associated steatotic liver disease (MASLD) progression
Julio Aleman, Lawrence A. Vernetti, Mark E. Schurdak, Richard DeBiasio, Greg LaRocca, Vijay K. Yechoor, D. Lansing Taylor, Andrew M. Stern, Mark T. Miedel
This study demonstrates that a vascularized liver acinus microphysiological system recapitulates key features of MASLD progression and lipid-induced hepatic insulin resistance.
BMC Biotechnology · Apr 30, 2026Peer-reviewedBioengineering