Richard DeBiasio

Recapitulation of clinical and molecular hallmarks of lipid-induced hepatic insulin resistance in a zonated, vascularized human liver acinus microphysiological system during metabolic dysfunction-associated steatotic liver disease (MASLD) progression

This study demonstrates that a vascularized liver acinus microphysiological system recapitulates key features of MASLD progression and lipid-induced hepatic insulin resistance.

A metabolic-dysfunction associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system

This paper develops a coupled microphysiological system to study how liver dysfunction affects pancreatic islet function, finding altered secretomes and glucose responses under metabolic syndrome conditions.

Comparison of Wild-Type and High-risk PNPLA3 variants in a Human Biomimetic Liver Microphysiology System for Metabolic Dysfunction-associated Steatotic Liver Disease Precision Therapy

This study uses a human liver microphysiology system to compare the effects of PNPLA3 variants on MASLD progression and drug response.