Vijay K. Yechoor

This study identifies the circadian clock's role in coordinating the Notch-to-Wnt signaling switch to enhance regenerative myogenesis in muscle stem cells.

The paper identifies TEAD1 signaling as a critical regulator of chromaffin cell differentiation and function, and shows that SB699551 modulates this signaling to suppress pheochromocytoma cell proliferation.

This study shows the circadian clock coordinates Notch and Wnt signaling in muscle stem cells to regulate regeneration, with functional effects in dystrophic muscle and human myoblasts.

This study shows hepatocyte TEAD1 promotes fibrosis and inflammation in cholestatic liver injury but not bile acid metabolism, suggesting it as a therapeutic target in PSC.

This study identifies Quercetin and Fisetin as clock-activating compounds that inhibit adipocyte growth and lipid metabolism via RORα activation.

This study demonstrates that a vascularized liver acinus microphysiological system recapitulates key features of MASLD progression and lipid-induced hepatic insulin resistance.

This study shows HCMV infection disrupts chromatin organization and reduces TEAD1 activity through multiple mechanisms, linking it to genetic risk loci for eye and ear development.

This study shows naringenin modulates the circadian clock via RORα to suppress lipogenesis and promote adipose browning, improving metabolic health.

This study identifies TEAD1 as a direct regulator of NRF2 and oxidative stress response in cardiomyocytes, showing its critical role in maintaining antioxidant defenses and its downregulation in heart failure.

This paper develops a coupled microphysiological system to study how liver dysfunction affects pancreatic islet function, finding altered secretomes and glucose responses under metabolic syndrome conditions.

This study shows that BET inhibitor I-BET protects β-cells from cytokine-induced death and dysfunction by inhibiting NF-κB signaling and preserving key β-cell genes.

This study shows TEAD1 regulates adult β-cell proliferation and function, maintaining glucose homeostasis by balancing quiescence and mature identity in mice and humans.