The inflammasome of circulatory collapse: single cell analysis of survival on extracorporeal life support.
Eric J. Kort, Matthew J. Weiland, Edgars Grins, Emily Eugster, Hsiao-yun Milliron, Catherine E. Kelty, Nabin Manandhar Shrestha, Tomasz A. Timek, Marzia Leacche, Stephen J. Fitch, Theodore J. Boeve, Greg Marco, Michael G. Dickinson, Penny Wilton, Stefan V. Jovinge
The paper uses single-cell RNA sequencing to identify CD8+/CD52+ NKT cells as a survival predictor in patients on VA-ECLS, showing their inverse correlation with IL-6 production.
bioRxiv · Mar 7, 2020 · PreprintGenomics