Domain-specific quantification of prion protein in cerebrospinal fluid by targeted mass spectrometry
Eric Vallabh Minikel, Eric W. Kuhn, Alexandra R. Cocco, Sonia M. Vallabh, Christina R. Hartigan, Andrew G. Reidenbach, Jiri Safar, Gregory J. Raymond, Michael D. McCarthy, Rhonda O’Keefe, Franc Llorens, Inga Zerr, Sabina Capellari, Piero Parchi, Stuart L. Schreiber, Steven A. Carr
The paper develops a targeted mass spectrometry method to quantify prion protein in CSF, confirming that reduced PrP levels in prion disease are due to the disease process, not ELISA artifacts.
Molecular & Cellular Proteomics · Sep 26, 2019Peer-reviewedNeuroscience