Author

Rhonda O’Keefe

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Eric Vallabh MinikeliD· 2 shared Sonia M. VallabhiD· 2 shared Stuart L. SchreiberiD· 2 shared Alexandra R. CoccoiD· 1 shared Andrew G. ReidenbachiD· 1 shared Christina R. HartiganiD· 1 shared Deborah E. CabiniD· 1 shared Deborah McKenzie· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersNeuroscience

Eric Vallabh MinikelORCID

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2 papers

Recent·Most cited

NeuroscienceNucleic Acids ResearchPeer-reviewedJul 13, 2020

Prion protein lowering is a disease-modifying therapy across prion strains, disease stages, and endpoints

Eric Vallabh Minikel, Hien Tran Zhao, Jason Le…·Sonia M. Vallabh

This study shows that lowering prion protein expression with ASOs is effective in treating prion disease across different strains, treatment times, and endpoints.

142 citationstop 3%

mouseexperimental assay

𝕏 PostBluesky

NeuroscienceMolecular & Cellular ProteomicsPeer-reviewedSep 26, 2019

Domain-specific quantification of prion protein in cerebrospinal fluid by targeted mass spectrometry

Eric Vallabh Minikel, Eric W. Kuhn, Alexandra R. Cocco…·Steven A. Carr

The paper develops a targeted mass spectrometry method to quantify prion protein in CSF, confirming that reduced PrP levels in prion disease are due to the disease process, not ELISA artifacts.

25 citations

humanproteomics

𝕏 PostBluesky