Steven A. Carr

The paper develops scalable cell-free protein synthesis platforms to generate single-cell RNA-sequencing data on immune cell responses to cytokines and other signals, enabling functional discovery and drug target prioritization.

In 174 sedentary adults, resistance exercise changed more muscle molecular features than endurance exercise across omes and time points; network analysis nominates MEF2A and NFIC as regulatory hubs.

The paper presents initial findings from the MoTrPAC consortium, showing that acute and chronic exercise induce distinct physiological and molecular responses, with chronic training improving key health metrics.

The paper analyzes multi-omic, multi-tissue molecular responses to acute exercise in sedentary adults, identifying key pathways and exerkines involved in exercise effects.

This study identifies FAR1 as a key regulator of peroxisome degradation under hypoxia, linking ether lipid metabolism to autophagy and cardioprotection.

This paper designs a new proximity labeling enzyme, FlexID, using computational methods to improve spatial precision and versatility for mapping protein interactions and proteomes.

This study identifies DeSI1 as a cyclin D-CDK4/6 substrate whose phosphorylation regulates membrane and mitochondrial protein supply during proliferation.

This study identifies PSMε as a key molecular component that drives CD8+ T cell activation by commensal bacteria, offering a mechanism for immunotherapy without live bacterial colonization.

This paper introduces seed-guided diffusion-based design to improve structural diversity and target contact in antitoxin protein binders, achieving functional binders with enhanced selectivity.

This study uses in-situ glial cell-surface proteomics in Drosophila to identify DIP-β as a pro-longevity factor regulated by glial cells.

This study establishes quality control standards for single-cell proteomics through inter-laboratory benchmarking, identifying software and technical factors affecting data reliability.

This study identifies a therapeutic target, the entrapment complex, that clears toxic protein accumulation in distinct proteinopathies by disrupting a cargo receptor complex.

This paper identifies a PTP activity-independent mechanism by which SHP2 promotes RAS/ERK activation through direct binding to SOS1.

The paper identifies 25% of 7,264 non-canonical open reading frames (ncORFs) as producing translated gene products, supported by over 3,000 peptides from 3.8 billion mass spectra.

The paper maps the Drosophila secretome to identify tissue-specific origins and inter-organ trafficking of 535 blood plasma proteins.

The paper identifies tissue-specific transcriptional regulatory programs in rats undergoing endurance exercise training by integrating chromatin accessibility, DNA methylation, and gene expression data.

The paper introduces endocytome profiling to map cell-surface protein dynamics in developing olfactory receptor neurons, revealing how endocytosis regulates axon pruning and targeting.

The paper uses spatial omics to analyze translational dysregulation in Grin2a+/- mice, finding gene-specific translation reductions in neurons and non-neuronal cells linked to schizophrenia pathophysiology.

The paper shows UV exposure causes misfolded melanosomal proteins to aggregate, contributing to skin pigmentation disorders and melanocyte dysfunction.

This paper develops a mass spectrometry-based method to profile single-cell histone post-translational modifications, demonstrating its ability to detect treatment responses and chromatin heterogeneity.

This study investigates Akap11 mutant mice to explore the neurobiological effects of AKAP11 loss, finding increased PKA activity and transcriptomic changes linked to schizophrenia and bipolar disorder.

This study identifies HIF2-driven PTHrP as a cause of cachexia and hypercalcemia in kidney cancer and shows that HIF2 inhibitors can alleviate these symptoms.

This study shows that GPR34 maintains microglial homeostasis and limits disease-associated microglial responses in Alzheimer's disease models.

This study compares two surface proteomics methods for analyzing CSPs in low-input and cryopreserved samples, showing high reproducibility and identifying over 700 CSPs.

This study identifies sex-specific multi-omic responses to endurance exercise training in rat lungs, revealing differences in immune pathways and mitochondrial acetylation between males and females.

This study identifies two mechanisms that rescue DNMT3A R882H activity by analyzing combinatorial mutations and showing R882H promotes aberrant oligomerization.

This study identifies rare tumor-reactive T cells and conserved antigen repertoires in multiple myeloma and acute myeloid leukemia, developing a TCR fitness model to predict immunotherapy response.

This study evolves a laccase enzyme for cell surface labeling and EM, showing it can map T cell surface changes and visualize cell features without toxic H2O2.

This study identifies DNA hypomethylation, not DNA damage, as the primary mechanism of azacytidine and decitabine anti-cancer activity, linking it to chromatin regulators like USP48.