Detection of Pre-Existing Immunity to Bacterial Cas9 Proteins in People with Cystic Fibrosis
Gregory Serpa, Qiaoke Gong, Mithu De, Pranav S. J. B. Rana, Christopher P. Montgomery, Daniel J. Wozniak, Matthew E. Long, Emily A. Hemann
The paper assesses pre-existing immunity to Cas9 proteins in people with cystic fibrosis and finds similar antibody and T cell responses to S. aureus and S. pyogenes Cas9 compared to non-CF controls.
ImmunoHorizons · Sep 17, 2025Peer-reviewedImmunology