Emily A. Hemann

This study shows that Caspase-11 worsens severe SARS-CoV-2 by increasing inflammation and reducing CD8 T-cell immunity, but its removal improves viral clearance and survival.

This paper identifies lineage-specific chromatin accessibility differences at IFN gene loci in pDCs and epithelial cells, revealing ETS-IRF composite elements as key regulators of divergent interferon responses.

This study identifies Aiolos as a negative regulator of antigen-inexperienced, virtual memory CD8+ T cells, showing increased TVM cell numbers and function in its absence.

The paper assesses pre-existing immunity to Cas9 proteins in people with cystic fibrosis and finds similar antibody and T cell responses to S. aureus and S. pyogenes Cas9 compared to non-CF controls.

This study shows that IFITM3 knockout mice are a viable preclinical model for testing influenza vaccines due to their enhanced viral replication and functional immune responses.