Ligand-Induced Structural Dynamics Drive Allosteric Regulation of Translation Initiation Factor eIF4E
Agnese Roscioni, Vincenzo Maria D’Amore, Jesmina Rexha, Greta R. Bianchini, Anna La Teana, Daniele Di Marino, Alice Romagnoli, Francesco Saverio Di Leva
This study investigates how two structurally similar ligands, 4EGI-1 and i4EG-BiP, regulate eIF4E through distinct binding modes, revealing that frontal binding promotes 4E-BP1 over eIF4G interaction.
bioRxiv · Dec 23, 2025 · PreprintBiophysics