Daniele Di Marino

This paper develops a peptidomimetic inhibitor of eIF4E that suppresses cap-dependent translation in cancer and neurodevelopmental disorders, showing efficacy in cell and animal models.

This study investigates how two structurally similar ligands, 4EGI-1 and i4EG-BiP, regulate eIF4E through distinct binding modes, revealing that frontal binding promotes 4E-BP1 over eIF4G interaction.

The paper identifies genomic signatures of adaptation to high-altitude environments in the ant Tetramorium alpestre and links them to physiological adaptations.

This study identifies CAP2 as a regulator of Cofilin in synaptic plasticity, showing its role in LTP and its disruption in Alzheimer’s disease.

This study shows that deleting the KH1 domain of Fmr1 in rats causes attention deficits and transcriptional changes in the medial prefrontal cortex, similar to FXS, and identifies potential therapeutic targets.