Author

Jesmina Rexha

Marche Polytechnic UniversityORCID 0000-0002-5775-6875Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:deep learning· 1 Organism:Drosophila· 1 Approach:experimental assay· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Agnese RoscioniiD· 2 shared Alice RomagnoliiD· 2 shared Anna La TeanaiD· 2 shared Daniele Di MarinoiD· 2 shared Alberto MartireiD· 1 shared Alessandro GoriiD· 1 shared Anastasia De LucaiD· 1 shared Andrea CavalliiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersBiochemistry

Agnese RoscioniORCID

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2 papers

Recent·Most cited

A CYFIP1-Inspired Peptidomimetic Modulates eIF4E-Dependent Translational Control in Cancer and Neurodevelopmental Disorders

Alice Romagnoli, Omar Josue Alsina Gutierrez, Stefano Raniolo, Alessandro Gori, Kyriaki Foka, Anastasia De Luca, Jacopo Sgrignani, Jesmina Rexha, Agnese Roscioni, Greta Bergamaschi, Zaira Boussadia, Rita Pepponi, Gloria Venturini, Andrea Cavalli, Tiziana Borsello, , Vittorio Limongelli

This paper develops a peptidomimetic inhibitor of eIF4E that suppresses cap-dependent translation in cancer and neurodevelopmental disorders, showing efficacy in cell and animal models.

bioRxiv · May 8, 2026 · PreprintBiochemistry

Ligand-Induced Structural Dynamics Drive Allosteric Regulation of Translation Initiation Factor eIF4E

Agnese Roscioni, Vincenzo Maria D’Amore, Jesmina Rexha, Greta R. Bianchini, Anna La Teana, Daniele Di Marino, Alice Romagnoli, Francesco Saverio Di Leva

This study investigates how two structurally similar ligands, 4EGI-1 and i4EG-BiP, regulate eIF4E through distinct binding modes, revealing that frontal binding promotes 4E-BP1 over eIF4G interaction.

bioRxiv · Dec 23, 2025 · PreprintBiophysics