Agnese Roscioni

This study investigates how gain-of-function variants in the Kv7.2 channel's activation gate stabilize a partially open conformation, enabling K+ permeation and linking it to neurodevelopmental disorders.

This paper develops a peptidomimetic inhibitor of eIF4E that suppresses cap-dependent translation in cancer and neurodevelopmental disorders, showing efficacy in cell and animal models.

This study investigates how two structurally similar ligands, 4EGI-1 and i4EG-BiP, regulate eIF4E through distinct binding modes, revealing that frontal binding promotes 4E-BP1 over eIF4G interaction.

This study identifies two KCNQ2 variants causing developmental encephalopathies by constitutively opening the Kv7.2 pore activation gate, leading to gain-of-function effects.