SpxA1 and SpxA2 Function as a Stoichiometry-Dependent Regulatory Rheostat Governing Virulence Gene Expression in Group A Streptococcus
Gretchen A. Morrison, Luis Alberto Vega, Misu Ailin Sanson Iglesias, Khufu Holly, William Hayes McDonald, Nicola Horstmann, Samuel A. Shelburne, Jennifer Angeline Gaddy, Anthony R. Flores
This study identifies SpxA1 and SpxA2 as regulators of virulence gene expression in GAS, showing their stoichiometric balance determines transcriptional programs through interactions with CovR.
mBio · Aug 4, 2026Peer-reviewedMicrobiology