Author

William Hayes McDonald

Vanderbilt UniversityORCID 0000-0002-3510-426XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Anthony R. FloresiD· 1 shared Gretchen A. Morrison· 1 shared Hassane S. MchaourabiD· 1 shared Hillary M. LaydeniD· 1 shared Jacob D. Ellis· 1 shared Jennifer Angeline GaddyiD· 1 shared Jing WangiD· 1 shared Kevin L. ScheyiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperMicrobiology

Anthony R. FloresORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

MicrobiologymBioPeer-reviewedAug 4, 2026

SpxA1 and SpxA2 Function as a Stoichiometry-Dependent Regulatory Rheostat Governing Virulence Gene Expression in Group A Streptococcus

Gretchen A. Morrison, Luis Alberto Vega, Misu Ailin Sanson Iglesias…·Anthony R. Flores

This study identifies SpxA1 and SpxA2 as regulators of virulence gene expression in GAS, showing their stoichiometric balance determines transcriptional programs through interactions with CovR.

DOI 10.1128/mbio.01650-26

humanbulk RNA-seq

𝕏 PostBluesky

Molecular BiologyJournal of the American Society for Mass SpectrometryPeer-reviewedJun 9, 2025

Data-independent acquisition parallel accumulation-serial fragmentation (diaPASEF) analysis of the separated zebrafish lens improves identifications

Sarah R. Zelle, William Hayes McDonald, Kristie Lindsey Rose…·Kevin L. Schey

The paper uses diaPASEF proteomics to analyze zebrafish lens regions, achieving higher peptide and protein identifications compared to standard DIA methods.

2 citations

zebrafishproteomics

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Molecular BiologyMolecular CellPeer-reviewedNov 16, 2022

PAX3-FOXO1 coordinates enhancer architecture, eRNA transcription, andRNA polymerase pause release at select gene targets

Susu Zhang, Jing Wang, Qi Liu…·Kristy R. Stengel

This study uses a chemical-genetic approach to show that PAX3-FOXO1 regulates enhancer architecture, eRNA transcription, and RNA polymerase pause release at specific gene targets.

39 citations

humanChIP-seq

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