Jennifer Angeline Gaddy

SpxA1 and SpxA2 Function as a Stoichiometry-Dependent Regulatory Rheostat Governing Virulence Gene Expression in Group A Streptococcus

This study identifies SpxA1 and SpxA2 as regulators of virulence gene expression in GAS, showing their stoichiometric balance determines transcriptional programs through interactions with CovR.

A novel C57BL/6 mouse model for the study of severe Citrobacter rodentium infection

This paper develops a non-genetically modified C57BL/6 mouse model that develops severe Citrobacter rodentium infection, driven by microbiota changes and impaired early immunity.

Genomic adaptation in group B Streptococcus following intrapartum antibiotic prophylaxis and childbirth

This study identifies genomic adaptations in group B Streptococcus (GBS) following intrapartum antibiotic prophylaxis, showing increased mutation rates and biofilm production in persistent colonizers.

The effects of breastmilk-derived osteopontin on the intestinal intraepithelial lymphocyte compartment

This study investigates the role of breastmilk-derived osteopontin in intestinal intraepithelial lymphocyte (IEL) development in mice, showing its importance in IELs but no clear impact on disease susceptibility.

A CRISPRi Library Screen in Group B Streptococcus Identifies Surface Immunogenic Protein (Sip) as a Mediator of Multiple Host Interactions

This study uses CRISPRi to identify Sip as a key surface protein in GBS that modulates host interactions and pathogenesis.