Anthony R. Flores

SpxA1 and SpxA2 Function as a Stoichiometry-Dependent Regulatory Rheostat Governing Virulence Gene Expression in Group A Streptococcus

This study identifies SpxA1 and SpxA2 as regulators of virulence gene expression in GAS, showing their stoichiometric balance determines transcriptional programs through interactions with CovR.

LiaR-dependent gene expression contributes to antimicrobial responses in group A Streptococcus

This study identifies the LiaFSR regulon in Group A Streptococcus and shows how phosphorylated LiaR regulates virulence and AMP resistance via SpxA2 and other genes.

Emergent emm4 group A Streptococcus evidences a survival strategy during interaction with immune effector cells

This study identifies a survival strategy in emm4 group A Streptococcus strains through downregulation of SLO and upregulation of msrAB, enabling better macrophage survival without increased virulence.

Identification of a Chimeric M4 Protein and Novel Emm Pattern in Currently Circulating Strains of Emm4 Group A Streptococcus

The paper identifies a chimeric M4 protein and a novel Emm pattern in emm4 GAS strains due to an emm/enn gene fusion, which replaced pattern E strains in Houston over four years.