Neutrophil-Derived S100A8/A9 Drives Inflammation that Promotes Dnmt3a -Mutant Hematopoiesis
Jayna J. Mistry, Natalie R Fournier, Griffin J. Nye, Jennifer J. Trowbridge
This study identifies neutrophil-derived S100A8/A9 as a driver of inflammation that promotes Dnmt3a-mutant hematopoiesis, with tasquinimod reducing inflammatory cytokines and mutant HSPC levels.
bioRxiv · Jun 27, 2026 · PreprintCell Biology