Jennifer J. Trowbridge

SupeRJump identifies differentiation fate and discontinuous transitions in leukemia using a semi-supervised jump diffusion model applied to scRNA-seq data.

This study shows that aging-related retrotransposon activation in stromal cells promotes Dnmt3a-mutant clonal hematopoiesis through inflammation.

This study identifies neutrophil-derived S100A8/A9 as a driver of inflammation that promotes Dnmt3a-mutant hematopoiesis, with tasquinimod reducing inflammatory cytokines and mutant HSPC levels.

The paper identifies an age-related expansion of an inflammatory and quiescent HSC subpopulation using integrated single-cell data.

This study compares the biological outcomes of gamma- and X-ray irradiation in mouse hematopoietic and AML transplants, finding they are functionally equivalent with proper dose calibration.

The paper characterizes an Osmr conditional knockout mouse model, showing variable tissue-dependent effects on OSMR mRNA and protein expression.

The paper examines how histone modifications vary across mouse strains and correlates these variations with gene expression, finding strong links between chromatin states and gene expression, but not DNA methylation.