Ewelina Bolcun‐Filas

This study compares the biological outcomes of gamma- and X-ray irradiation in mouse hematopoietic and AML transplants, finding they are functionally equivalent with proper dose calibration.

The paper uses single-cell and bulk RNA sequencing to study DNA damage response in mouse ovaries, identifying novel genes and pathways specific to oocytes.

This study shows that inhibiting CHEK2 protects primordial oocytes from chemotherapy-induced damage, suggesting it could be used to preserve ovarian function in cancer patients.

The paper shows that sex-specific modifiers, like CHK2, allow female fertility without PRDM9, revealing sex-specific regulation of meiotic recombination.

The paper shows that the CHK2-dependent checkpoint eliminates mouse oocytes with DNA damage or synapsis failure by detecting and removing those with unrepaired DSBs or unsynapsed chromosomes.