The transcriptional regulatory circuit as a driver and therapeutic target in CML blast crisis
Liling Jiang, Enzhe Lou, Jinxin Fang, Lizhen Jiang, Guanjie Peng, Jinghong Chen, Bingyuan Liu, Jiahong Lu, Yi Meng, Haichuan Zhang, Aochu Liu, Qiong Mao, Peilong Lai, Yueyuan Zheng, Jinbao Liu, Xianping Shi
This study identifies a transcriptional circuit in CML blast crisis that drives disease progression and shows mebendazole can inhibit it, offering a potential therapeutic strategy.
bioRxiv · Nov 2, 2025 · PreprintCancer Biology