Author

Yueyuan Zheng

The Seventh Affiliated Hospital of Sun Yat-sen UniversityORCID 0000-0002-5692-8903Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3 Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

De‐Chen LiniD· 3 shared Qiong MaoiD· 3 shared Hua ZhaoiD· 2 shared Young Min ParkiD· 2 shared Alice SoragniiD· 1 shared Amir EdeniD· 1 shared Anette Vistoro Monreal· 1 shared Aochu Liu· 1 shared

Activity by Year

2022-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCancer Biology

De‐Chen LinORCID

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Author profile →

5 papers

Recent·Most cited

PlotGDP: an AI Agent for Bioinformatics Plotting

Xiaotong Luo, Ying Shi, Hao Huang, Hongge Wang, Wenyi Cao, Zhixiang Zuo, Qi Zhao, Yueyuan Zheng, Yubin Xie, Shuai Jiang, Jian Ming Ren

PlotGDP provides an AI-powered web server for generating publication-quality bioinformatics plots using natural language commands without requiring coding or environment setup.

bioRxiv · Feb 7, 2026 · PreprintBioinformatics

The transcriptional regulatory circuit as a driver and therapeutic target in CML blast crisis

Liling Jiang, Enzhe Lou, Jinxin Fang, Lizhen Jiang, Guanjie Peng, Jinghong Chen, Bingyuan Liu, Jiahong Lu, Yi Meng, Haichuan Zhang, Aochu Liu, Qiong Mao, Peilong Lai, Yueyuan Zheng, Jinbao Liu, Xianping Shi

This study identifies a transcriptional circuit in CML blast crisis that drives disease progression and shows mebendazole can inhibit it, offering a potential therapeutic strategy.

bioRxiv · Nov 2, 2025 · PreprintCancer Biology

Genomic and single-cell characterization of patient-derived tumor organoid models of head and neck squamous cell carcinoma

Jung Hyun Um, Yueyuan Zheng, Qiong Mao, Chehyun Nam, Hua Zhao, Yoon Woo Koh, Su‐Jin Shin, Young Min Park, De‐Chen Lin

This study establishes patient-derived tumor organoids (PDOs) from 31 HNSCC patients, faithfully recapitulating tumor characteristics and predicting cisplatin responses, revealing hEMT-driven resistance and AREG as a therapeutic target.

Cancer Research · Apr 22, 2025Peer-reviewedCancer Biology

Genetically Defined Organoid Models Reveal Mechanisms Driving Squamous Cell Neoplastic Evolution and Identify Potential Therapeutic Vulnerabilities

Hua Zhao, Young Min Park, Yueyuan Zheng, Qiong Mao, Casey Collet, Boyan Hu, Tianming Zhou, Luda Lin, Stephanie K. Wong, Yuhao Pan, Anette Vistoro Monreal, Uttam K. Sinha, Parish Paymon Sedghizadeh, Alice Soragni, De‐Chen Lin

bioRxiv · Jan 18, 2025 · PreprintCancer Biology

A local sequence signature defines a subset of heterochromatin-associated CpGs with minimal loss of methylation in healthy tissues but extensive loss in cancer

Dror Bar, Lior Fishman, Yueyuan Zheng, Irene Unterman, Devorah Schlesinger, Amir Eden, De‐Chen Lin, Benjamin P. Berman

The paper identifies a sequence signature that predicts CpG methylation loss in healthy tissues and cancer, revealing slow-loss CpGs with minimal methylation loss in health but significant loss in cancer.

bioRxiv · Aug 16, 2022 · PreprintGenomics