A robust evaluation of TDP-43, poly GP, cellular pathology, and behavior in a AAV-C9ORF72 (G4C2)66 mouse model
Emily G. Thompson, Olivia Spead, Sigvard Åkerman, Carrie Curcio, Benjamin L. Zaepfel, Erica R. Kent, Thomas Philips, Balaji G. Vijayakumar, Anna Zacco, Weibo Zhou, Guhan Nagappan, Jeffrey D. Rothstein
This study evaluates a mouse model of C9-ALS/FTD, finding it robust for molecular mechanisms but not for neurodegeneration and motor deficits.
bioRxiv · Aug 27, 2024 · PreprintNeuroscience