A phenotypic screen identified KEAP1-kelch domain blockade as a mechanism to restore cardiac function in the setting of chronic severe hemodynamic stress
John J. Upson, Christine G. Schnackenberg, Brian G. Lawhorn, Quanhai Chen, Daniel T. Sweet, Thimmaiah P. Chendrimada, Carl A. Brooks, Mark E. Burgert, Christopher T Louer, Anna Zacco, Ian Moench, Jonathan B. Basilla, Joseph G. Boyer, Christine Y. Ivashchenko, Sharada Manns, , John R. Toomey
A gene expression-based screen in iPSC-CMs identified KEAP1-kelch domain blockers as effective in restoring cardiac function under chronic hemodynamic stress.
bioRxiv · Sep 24, 2025 · PreprintMolecular Biology