Astrocyte MCT1 expression does not contribute to the axonal degenerative phenotype observed with ubiquitous MCT1 depletion.
Thomas Philips, Emily G. Thompson, Olivia Spead, Balaji G. Vijayakumar, Erica R. Kent, Sean Miller, Treasure Nwokeleme, Svetlana Vidensky, Mohamed H. Farah, Jeffrey D. Rothstein
This study shows that astrocyte MCT1 depletion does not cause axonal degeneration, unlike oligodendrocyte MCT1 depletion, suggesting astrocyte MCT1 is not essential for axonal energy homeostasis with aging.
Glia · Dec 2, 2025Peer-reviewedNeuroscience