Tau reduction counteracts transcriptomic and behavioral abnormalities in an Alzheimer amyloid model
Sara J. Knowles, Cathrine Sant, Pranav Nambiar, Rafaella Araujo Gonçalves, Kaitlyn Ho, Gui-Qiu Yu, Reuben Thomas, Megumi Mori, Lane Domke, Victor Huang, Nicholaus A. Smith, Iris Lo, Stephanie R. Miller, M. Ryan Corces, Jorge J. Palop, Lennart Mucke
This study shows that reducing tau mitigates transcriptomic and behavioral issues in an Alzheimer's model without affecting amyloid levels.
bioRxiv · Aug 4, 2026 · PreprintNeuroscience