Author

Lane Domke

Gladstone Institutes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Assay:proteomics· 1

Frequent Co-Authors

Adeline J. H. YongiD· 1 shared Alma L. BurlingameiD· 1 shared Angelina Koroknay· 1 shared Cathrine Sant· 1 shared Chao CheniD· 1 shared Gui-Qiu Yu· 1 shared Iris LoiD· 1 shared Jeffrey A. Simms· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Adeline J. H. YongORCID

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2 papers

Recent·Most cited

Calcium-dependent synaptic proteomics reveals EGFR signaling at active synapses

Adeline J. H. Yong, Yuh Nung Jan, Juan A. Osés-Prieto, Tong Cheng, Chao Chen, Lane Domke, Mario V. Zubia, Angelina Koroknay, Jeffrey A. Simms, Alma L. Burlingame, Lily Yeh Jan, Nicholas T. Ingolia, Jungwoo Wren Kim, Yuh Nung Jan

The paper develops a method to profile synaptic proteomes under physiological conditions and identifies EGFR signaling as a key activity-dependent process at synapses.

bioRxiv · Aug 22, 2026 · PreprintNeuroscience

Tau reduction counteracts transcriptomic and behavioral abnormalities in an Alzheimer amyloid model

Sara J. Knowles, Cathrine Sant, Pranav Nambiar, Rafaella Araujo Gonçalves, Kaitlyn Ho, Gui-Qiu Yu, Reuben Thomas, Megumi Mori, Lane Domke, Victor Huang, Nicholaus A. Smith, Iris Lo, Stephanie R. Miller, M. Ryan Corces, Jorge J. Palop, Lennart Mucke

This study shows that reducing tau mitigates transcriptomic and behavioral issues in an Alzheimer's model without affecting amyloid levels.

bioRxiv · Aug 4, 2026 · PreprintNeuroscience