Author

Iris Lo

Gladstone InstitutesORCID 0000-0003-4905-9612Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Jeffrey A. Simms· 2 shared Alex ZhangiD· 1 shared Alexis Madrid· 1 shared Alice An· 1 shared Alice TangiD· 1 shared Ananth V. Kolli· 1 shared Antara T. RaoiD· 1 shared Carlene A. ChinniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersNeuroscience

Jeffrey A. Simms

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintAug 4, 2026

Tau reduction counteracts transcriptomic and behavioral abnormalities in an Alzheimer amyloid model

Sara J. Knowles, Cathrine Sant, Pranav Nambiar…·Lennart Mucke

This study shows that reducing tau mitigates transcriptomic and behavioral issues in an Alzheimer's model without affecting amyloid levels.

DOI 10.64898/2026.08.03.741071

mousemachine learning (classical)

𝕏 PostBluesky

NeuroscienceMolecular PsychiatryPeer-reviewedNov 22, 2025

The GluA1 cytoplasmic tail regulates intracellular AMPA receptor trafficking and synaptic transmission onto dentate gyrus GABAergic interneurons, gating response to novelty

Gerardo Leana-Sandoval, Alexis Madrid, Ananth V. Kolli…·Javier Díaz-Alonso

This study investigates the role of the GluA1 cytoplasmic tail in AMPA receptor trafficking and synaptic transmission in dentate gyrus GABAergic interneurons, revealing its impact on behavior and neuronal activity.

DOI 10.1038/s41380-025-03328-y

mouseexperimental assay

𝕏 PostBluesky

Systems BiologybioRxivPreprintDec 9, 2024

Data-driven discovery of cell-type-directed network-correcting combination therapy for Alzheimer's disease

Yaqiao Li, Carlota Pereda Serras, Jessica R. Blumenfeld…·Marina Sirota

The paper identifies a cell-type-directed combination therapy for Alzheimer's disease using single-cell transcriptomics and drug databases, showing improved memory and reduced pathologies in a mouse model.

3 citations

𝕏 PostBluesky