Author

Lennart Mucke

Gladstone InstitutesORCID 0000-0001-6256-9559Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:machine learning (classical)· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Organism:mouse· 1 Assay:multiome· 1 Assay:scATAC-seq· 1 Assay:scRNA-seq· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Cathrine Sant· 2 shared M. Ryan CorcesiD· 2 shared Gui-Qiu Yu· 1 shared Iris LoiD· 1 shared Jorge J. PalopiD· 1 shared Kaitlyn Ho· 1 shared Lane Domke· 1 shared Megumi MoriiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Cathrine Sant

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintAug 4, 2026

Tau reduction counteracts transcriptomic and behavioral abnormalities in an Alzheimer amyloid model

Sara J. Knowles, Cathrine Sant, Pranav Nambiar…·Lennart Mucke

This study shows that reducing tau mitigates transcriptomic and behavioral issues in an Alzheimer's model without affecting amyloid levels.

DOI 10.64898/2026.08.03.741071

mousemachine learning (classical)

𝕏 PostBluesky

BioinformaticsNature GeneticsPeer-reviewedApr 7, 2025

CHOIR improves significance-based detection of cell types and states from single-cell data

Cathrine Sant, Lennart Mucke, M. Ryan Corces

CHOIR improves cell type and state detection in single-cell data by using statistical inference to assess clustering results, outperforming existing methods across multiple data types.

24 citationstop 2%

scRNA-seqscATAC-seq

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