Voltage-sensor trapping of cardiac Na+ channels by Mg-protoporphyrin impairs cancer cell migration
Mahdi Jamili, Marwa Ahmed, Alisa Bernert, Johann Rossler, Guido Geßner, Roland Schönherr, Toshinori Hoshi, Stefan H. Heinemann
This study identifies MgPpIX as a potent and specific inhibitor of hNaV1.5, which suppresses cancer cell migration.
bioRxiv · Jul 28, 2025 · PreprintPhysiology