Toshinori Hoshi

Structural compatibility enables functional co-assembly of Kir2.1 channels and the voltage-sensing domain of voltage-sensitive phosphatases

This study shows that Kir2.1 channels and voltage-sensing domains can co-assemble into functional KV-like complexes, altering voltage-dependent fluorescence responses.

Voltage-sensor trapping of cardiac Na+ channels by Mg-protoporphyrin impairs cancer cell migration

This study identifies MgPpIX as a potent and specific inhibitor of hNaV1.5, which suppresses cancer cell migration.

Disease-associated Kv1.3 variants are energy compromised with impaired nascent chain folding.

This study investigates how disease-associated Kv1.3 variants affect protein folding and stability, finding that R114G variant shows reduced folding probability and structural instability.

Decreased KATP channel activity contributes to the low glucose threshold for insulinsecretion in the early postnatal period

The paper shows that decreased KATP channel surface density in early postnatal rat beta-cells lowers the glucose threshold for insulin secretion, which normalizes by postnatal day 14.

Early postnatal activation of the hypoxia pathway disrupts β-cell function

This study shows that early postnatal activation of the HIF1A pathway in rats causes hyperinsulinism and reduced β-cell proliferation, potentially increasing diabetes risk.