The role of CYP3A-CYP2E1 interactions in activation of CYP3A enzymes by chronic alcohol exposure
Dmitri R. Davydov, Kannapiran Ponraj, Nadezhda Y. Davydova, Guihua Yue, Dilip Kumar Singh, Arpita Guha Neogi, Kari A. Gaither, Bhagwat Prasad
This study investigates how chronic alcohol exposure increases CYP3A enzyme activity in human liver microsomes through interactions with CYP2E1, despite no change in CYP3A levels.
Biochemical Journal · Aug 3, 2026Peer-reviewedBiochemistry