Kannapiran Ponraj

This study investigates how chronic alcohol exposure increases CYP3A enzyme activity in human liver microsomes through interactions with CYP2E1, despite no change in CYP3A levels.

This paper introduces a new fluorogenic substrate, MONA, for CYP1A2 and uses it to study how chronic alcohol exposure affects CYP1A2 activity in human liver microsomes.

This study investigates how alcohol consumption and smoking affect drug-metabolizing enzymes and transporters in human liver microsomes, identifying significant changes in enzyme abundance and proposing an alcohol exposure index.

The paper investigates how alcohol affects drug metabolism by analyzing interactions between P450 enzymes in human liver microsomes, finding alcohol increases low-affinity enzyme roles and alters enzyme-specific metabolic rates.