A genome-wide atlas of human cell morphology
Meraj Ramezani, Erin Weisbart, Julia Bauman, Avtar K Singh, John Yong, Maria Lozada, Gregory P. Way, Sanam L. Kavari, Celeste Diaz, Eddy Leardini, Gunjan Jetley, Jenlu Pagnotta, Marzieh Haghighi, Thiago M. Batista, Joaquín Pérez‐Schindler, , James T. Neal
The paper presents a genome-wide perturbation atlas using CRISPR-Cas9 knockouts to link genes to cellular phenotypes, identifying TMEM251/LYSET as a Golgi-resident protein involved in lysosomal enzyme trafficking.
Nature Methods · Jan 27, 2025Peer-reviewedGenomics