Calvin H. Jan

This study identifies senescent cells as drivers of age-related inflammation in adipose tissue by inducing vascular MHC II and recruiting CD4+ T cells through an IFN-gamma feedback loop.

The paper analyzes genetic diversity in naked mole-rats from Kenya and Ethiopia using whole-genome sequencing and a chromosome-scale genome assembly, revealing unexpected genetic divergence patterns.

The paper introduces CRISPuRe-seq, a pooled CRISPR screening method that identifies genetic perturbations affecting protein-based phenotypes, and demonstrates its use in uncovering components of the type 1 Interferon JAK/STAT pathway.

The paper presents a genome-wide perturbation atlas using CRISPR-Cas9 knockouts to link genes to cellular phenotypes, identifying TMEM251/LYSET as a Golgi-resident protein involved in lysosomal enzyme trafficking.