Biophysical Modeling Elucidates Mechanistic Principles for Rational Molecular Glue Design
Seok Joo Chae, Jonathon DeBonis, Joseph Quinlan, Ryan Richards, Junmin Wang, Gustavo J. Gutierrez, Jonathan Tart, Maxime Couturier, Sergio Martínez Cuesta, Meizhong Jin, Oleg A. Igoshin
This paper develops a mathematical framework to analyze molecular glues, showing that strong ternary complex binding affinity is key for performance, with degrader performance limited by catalytic efficiency and target half-life.
Journal of Chemical Information and Modeling · Apr 13, 2026Peer-reviewedMolecular Biology