Sergio Martínez Cuesta

This paper develops a mathematical framework to analyze molecular glues, showing that strong ternary complex binding affinity is key for performance, with degrader performance limited by catalytic efficiency and target half-life.

RP3Net predicts recombinant protein production in E. coli using deep learning, achieving 77% accurate predictions and 92% correct identification of expressing constructs.

This study shows that 5-formylcytosine (5fC) influences nucleosome positioning through covalent histone-DNA interactions in mouse embryonic stem cells.