Bioisosteric analogs of MDMA with improved pharmacological profile
A. S. Alberto-Silva, S. Hemmer, H. A. Bock, L. Alves da Silva, K. R. Scott, N. Kastner, M. Bhatt, M. Niello, K. Jantsch, O. Kudlacek, E. Bossi, T. Stockner, M. R. Meyer, J. D. McCorvy, S. D. Brandt, , H. H. Sitte
This study evaluates three MDMA bioisosteres for improved pharmacological profiles, finding reduced off-target receptor activity and altered hepatic metabolism compared to MDMA.
bioRxiv · Apr 8, 2024 · PreprintPharmacology & Toxicology