Novel enhancers of guanylyl cyclase-A activity via allosteric modulation
H. Andresen, C. Perez-Ternero, J. Robinson, D. M. Dickey, A. J. Hobbs, L. R. Potter, F. O. Levy, A. Cataliotti, L. R. Moltzau
The paper identifies small molecule allosteric enhancers of GC-A that increase ANP and BNP signaling without using known binding sites or mechanisms.
bioRxiv · Dec 31, 2021Pharmacology & Toxicology