Both DNA binding domains of p53 are required for its ultra rapid recruitment to sites of UV damage
Y.-H. Wang, T. Ho, A. Hariharan, H. C. Goh, M. Sheetz, D. Lane
The paper shows p53 requires both DNA binding and C-terminal domains for ultra-rapid recruitment to UV damage sites, which is PARP-dependent and inhibited by cancer-associated mutations.
bioRxiv · Feb 9, 2020 · PreprintCell Biology