Y.-H. Wang

Re-defining how mRNA degradation is coordinated with transcription and translation in bacteria

This study investigates how mRNA degradation is coordinated with transcription and translation in bacteria, finding that RNase E localization and translation affect mRNA stability in Escherichia coli and other species.

Regulatory T cells and IFN-γ-producing Th1 cells play a critical role in the pathogenesis of Sjögren's Syndrome

This study identifies Treg cells and IFN-γ-producing Th1 cells as key drivers of Sjögren's Syndrome pathogenesis using a mouse model and single-cell transcriptomics.

Duhuo Jisheng Decoction Regulates Intracellular Zinc Homeostasis by Enhancing Autophagy via PTEN/Akt/mTOR to Improve Knee Cartilage Degeneration

This study investigates how Duhuo Jisheng Decoction protects cartilage by enhancing autophagy through the PTEN/Akt/mTOR pathway and regulating zinc homeostasis.

Attractant and repellent induce opposing changes in the chemoreceptor four-helix bundle ligand-binding domain

The paper identifies malate as a repellent recognized by the MCP2021 chemoreceptor in Comamonas testosteroni and shows how it induces opposing conformational changes compared to the attractant citrate.

Orai3 and Orai1 are essential for CRAC channel function and metabolic reprogramming in B cells

This study shows Orai1 and Orai3 are essential for CRAC channel function and metabolic reprogramming in B cells, impacting proliferation, survival, and metabolic processes.

Transcriptome-based phylogeny of the semi-aquatic bugs (Hemiptera: Heteroptera: Gerromorpha) reveals patterns of lineage expansion in a series of new adaptive zones

This study reconstructs the phylogeny of Gerromorpha using transcriptomic data and fossil records, revealing patterns of lineage expansion and phenotypic evolution following water surface invasion.

CUB domain containing protein 1 (CDPC1) is a target for radioligand therapy in castration resistant prostate cancer

This paper evaluates CDCP1 as a target for radioligand therapy in mCRPC, showing its expression in most biopsies and demonstrating antitumor effects with 177Lu-4A06.

Targeting a proteolytic neo-epitope of CUB-domain containing protein 1 in RAS-driven cancer

The paper develops antibodies targeting proteolytic neo-epitopes of CDCP1 in RAS-driven cancers, showing improved tumor specificity and safety.

Isolation and Characterization of Cross-Neutralizing Coronavirus Antibodies from COVID-19+ Subjects

The paper isolates and characterizes cross-neutralizing antibodies from COVID-19 patients, identifying antibodies that neutralize both SARS-CoV-1 and SARS-CoV-2, including variants.

Exploiting KRAS-driven Ferroaddiction in Cancer Through Ferrous Iron-Activatable Drug Conjugates (FeADC)

This paper develops FeADCs, ferrous iron-activatable drug conjugates, to target KRAS-driven cancers with improved tumor selectivity and systemic tolerability.

Both DNA binding domains of p53 are required for its ultra rapid recruitment to sites of UV damage

The paper shows p53 requires both DNA binding and C-terminal domains for ultra-rapid recruitment to UV damage sites, which is PARP-dependent and inhibited by cancer-associated mutations.

Mechanical Stretch Kills Transformed Cancer Cells

The paper shows that cyclic mechanical stretch induces apoptosis in transformed cancer cells but promotes growth in normal cells, with mechanoptosis driven by calcium influx and calpain activation.

Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of cerebellar CHIPopathy

This study investigates the effects of a CHIP mutation in preclinical models, showing it causes structural disruption and functional loss linked to motor and cognitive deficits.