Permeant Fluorescent Probes Visualize the Activation of SARM1 and Uncover an Anti-neurodegenerative Drug Candidate
W. H. Li, K. Huang, Y. Cai, Q. W. Wang, W. J. Zhu, Y. N. Hou, S. Wang, S. Cao, Z. Y. Zhao, X. J. Xie, Y. Du, C. Lee, H. C. Lee, H. Zhang, Y. J. Zhao
The paper develops fluorescent probes to visualize SARM1 activation and identifies a nisoldipine derivative as a SARM1 inhibitor that protects axons from degeneration.
bioRxiv · Feb 24, 2021Biochemistry