Author

Y. J. Zhao

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1 Approach:statistical model· 1 Assay:structural biology· 1 Organism:virus· 1

Frequent Co-Authors

B. Huang· 1 shared C. Lee· 1 shared D. Cao· 1 shared G. Zhang· 1 shared H. C. Lee· 1 shared H. Huang· 1 shared H. Zhang· 1 shared H. Zhou· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

B. Huang

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Author profile →

2 papers

Recent·Most cited

Permeant Fluorescent Probes Visualize the Activation of SARM1 and Uncover an Anti-neurodegenerative Drug Candidate

W. H. Li, K. Huang, Y. Cai, Q. W. Wang, W. J. Zhu, Y. N. Hou, S. Wang, S. Cao, Z. Y. Zhao, X. J. Xie, Y. Du, C. Lee, H. C. Lee, H. Zhang, Y. J. Zhao

The paper develops fluorescent probes to visualize SARM1 activation and identifies a nisoldipine derivative as a SARM1 inhibitor that protects axons from degeneration.

bioRxiv · Feb 24, 2021Biochemistry

Structural basis for the inhibition of the papain-like protease of SARS-CoV-2 by small molecules

Z. Fu, B. Huang, J. Tang, S. Liu, M. Liu, Y. Ye, Z. Liu, Y. Xiong, D. Cao, J. Li, X. Niu, H. Zhou, Y. J. Zhao, G. Zhang, H. Huang

The paper identifies GRL0617 as a non-covalent inhibitor of SARS-CoV-2 PLpro with an IC50 of 2.1 μM, supported by co-crystal and NMR data showing its mechanism of action.

bioRxiv · Jul 17, 2020 · PreprintBiochemistry