Identification of a unique TCR repertoire, consistent with a superantigen selection process in Children with Multi-system Inflammatory Syndrome
R. A. Porritt, L. Paschold, M. Noval Rivas, M. H. Cheng, L. M. Yonker, H. Chandnani, M. Lopez, D. Simnica, C. Schultheiss, C. Santiskulvong, J. Van Eyk, A. Fasano, I. Bahar, M. Binder, M. Arditi
This study identifies a skewed TCR repertoire in MIS-C patients, with TRBV11-2 expansion linked to disease severity and superantigen-like interactions with SARS-CoV-2 spike protein.
bioRxiv · Nov 9, 2020 · PreprintImmunology